Takeoka Lab

Motor control by sensory feedback

Aya 300 340 C1

Aya Takeoka, PhD

Principal Investigator

Contact & Bio

We study how animals generate and control motor behavior in health and disease

Research areas

  • Motor circuit function and connectivity for motor learning and recovery after neurotrauma
  • Role of sensory feedback circuits in motor learning and control

Approaches

  • quantitative kinematic analyses
  • mouse genetics
  • virus-mediated circuit tracing and functional manipulations
  • in vivo electrophysiology

Our scientific questions

Almost everything we do in our daily lives are learned motor behavior. The central question that the Takeoka lab addresses is how animals learn to generate and control motor output in health and disease. In particular we study mechanisms of circuit assembly, function and plasticity that lead to motor learning and recovery after neurotrauma.

Team

Img 2144

Key publications

Ludwig Ruder, Aya Takeoka, Silvia Arber, Long-distance descending spinal neurons ensure quadrupedal locomotor stability, Neuron, 92(5): 1063-1078, 2016
Emanuela Basaldella, Aya Takeoka, Sigrist Markus, Silvia Arber, Multisensory signaling shapes vestibulo-motor circuit specificity, Cell 163(2), 301-312, 2015
Aya Takeoka, Isabel Vollenweider, Grégoire Courtine, Silvia Arber, Muscle spindle feedback directs locomotor recovery and circuit reorganization after spinal cord injury, Cell, 159(7), 1626-1639, 2014
Aya Takeoka, Devin L Jindrich, Cintia Muñoz-Quiles, Hui Zhong, Rubia van den Brand, Daniel L Pham, Matthias D Ziegler, Almudena Ramon-Cueto, Roland R Roy, V Reggie Edgerton, Patricia E Phelps, Axon regeneration can facilitate or suppress hindlimb function after olfactory ensheathing glia transplantation, Journal of Neuroscience 31 (11) 4298-4310, 2011
Aya Takeoka, Marc D Kubasak, Hui Zhong, Jennifer A Kaplan, Roland R Roy, Patricia E Phelps, Noradrenergic innervation of the rat spinal cord caudal to a complete spinal cord transection: Effects of olfactory ensheathing glia, Experimental Neurology, 222(1), 59-69, 2010
Aya Takeoka, Marc D Kubasak, Hui Zhong, Roland R Roy, Patricia E Phelps, Serotonergic innervation of the caudal spinal stump in rats after complete spinal transection: Effect of olfactory ensheathing glia, Journal of Comparative Neurology, 515(6), 664-676, 2009