Farrow Lab

From the eye to behaviour

Kf Karl Farrow Vib

Karl Farrow, PhD

Assistant Professor
Department of Biology, KU Leuven, Belgium

Contact & Bio

Dissecting the lines of communication
connecting the eye with behaviour

Many of the computations performed by the nervous system can be interpreted as answers to particular challenges posed by the live histories of an animal. However, it remains unknown how neural circuits are organized to carry out the computations that link specific sensory inputs with the activation of the appropriate behaviour.

To address these questions, we work with mice and Peromyscus to dissect the neural circuits that link the earliest stages of visual processing in the retina with the initiation of suitable behaviours. We combine trans‐synaptic viral tracing techniques with large scale brain recordings and optogenetic approaches to unravel the connectivity between targeted cell types, brain regions and behaviour.

The labs scientific questions

The primary purpose of our work is to determine the details of how information is disseminated and organized in the brain to enable the necessary computations that link sensory stimuli with the triggering of suitable behaviours. This is done to uncover fundamental principals of how the brain is organized, how defects in circuitry leads to brain dysfunction, and determine what aspects of this circuitry is conserved across evolution.

Team

Meet the members of the Farrow lab

Farrowlabpeople

Key publications

Daniel De Malmazet, Norma Kühn, Karl Farrow, Retinotopic Separation of Nasal and Temporal Motion Selectivity in the Mouse Superior Colliculus, Current Biology, 28(18), 2961-2969, 2018
Keisuke Yonehara, Karl Farrow, Ghanem Alexander, Daniel Hillier, Kamill Balint, Miguel Teixeira, Josephine Jüttner, Masaharu Noda, Rachael L Neve, Karl-Klaus Conzelmann, Botond Roska, The first stage of cardinal direction selectivity is localized to the dendrites of retinal ganglion cells, Neuron, 79(6), 1078-1085, 2013
Karl Farrow, Miguel Teixeira, Tamas Szikra, Tim J Viney, Kamill Balint, Keisuke Yonehara, Botond Roska, Ambient illumination toggles a neuronal circuit switch in the retina and visual perception at cone threshold., Neuron, 78(2): 325-338, 2013
Karl Farrow, Richard H Masland, Physiological clustering of visual channels in the mouse retina, Journal of Neurophysiology, 105(4):1516-30, 2011