Farrow Lab

From the eye to behaviour

Kf Karl Farrow Vib

Karl Farrow, PhD

Assistant Professor, Department of Biology, KU Leuven
Group leader, NERF and VIB
Member of the Leuven Brain Institute

Contact & Bio

Dissecting the lines of communication
connecting the eye with behaviour

Many of the computations performed by the nervous system can be interpreted as answers to particular challenges posed by the live histories of an animal. However, it remains unknown how neural circuits are organized to carry out the computations that link specific sensory inputs with the activation of the appropriate behaviour.

To address these questions, we work with mice and Peromyscus to dissect the neural circuits that link the earliest stages of visual processing in the retina with the initiation of suitable behaviours. We combine trans‐synaptic viral tracing techniques with large scale brain recordings and optogenetic approaches to unravel the connectivity between targeted cell types, brain regions and behaviour.

The labs scientific questions

The primary purpose of our work is to determine the details of how information is disseminated and organized in the brain to enable the necessary computations that link sensory stimuli with the triggering of suitable behaviours. This is done to uncover fundamental principals of how the brain is organized, how defects in circuitry leads to brain dysfunction, and determine what aspects of this circuitry is conserved across evolution.

Team

Meet the members of the Farrow lab

Farrowlabpeople

Key publications

Arnau Sans Dublanc, Anna Chrzanowska, Katja Reinhard, Dani Lemmon, Bram Nuttin, Théo Lambert, Gabriel Montaldo, Alan Urban, Karl Farrow, Optogenetic fUSI for brain-wide mapping of neural activity mediating collicular-dependent behaviors, Neuron,109, 1-18, 2021
Clément Brunner, Micheline Grillet, Arnau Sans Dublanc, Karl Farrow, Théo Lambert, Emilie Macé, Gabriel Montaldo, Alan Urban, A platform for brain-wide volumetric functional ultrasound imaging and analysis of circuit dynamics in awake mice, Neuron, 108, 861-875, 2020
Katja Reinhard, Chen Li, Quan Do, Emily G Burke, Steven Heynderickx, Karl Farrow, A projection specific logic to sampling visual inputs in mouse superior colliculus, eLife, 2019
Heather C. Rice, Daniel De Malmazet, An Schreurs, Samuel Frere, Inge Van Molle, Alexander N. Volkov, Eline Creemers, Irena Vertkin, Julie Nys, Fanomezana M. Ranaivoson, Davide Comoletti, Jeffrey N. Savas, Han Remaut, Detlef Balschun, Keimpe D. Wierda, Inna Slutsky, Karl Farrow, Bart De Strooper, Joris de Wit, Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission, Science, Vol. 363, Issue 6423, eaao4827, 2019
Daniel De Malmazet, Norma Kühn, Karl Farrow, Retinotopic Separation of Nasal and Temporal Motion Selectivity in the Mouse Superior Colliculus, Current Biology, 28(18), 2961-2969, 2018