Closed-loop optical neural stimulation based on a 32-channel low-noise recording system with online spike sorting

Nguyen TK, Bartic C, Battaglia FP, Gielen G, Wang L, Cabral H, Navratilova Z
Journal of Neural Engineering 11(4):046005, 2014

Closed-loop operation of neuro-electronic systems is desirable for both scientific and clinical (neuroprosthesis) applications.

OBJECTIVE:
Integrating optical stimulation with recording capability further enhances the selectivity of neural stimulation. We have developed a system enabling the local delivery of optical stimuli and the simultaneous electrical measuring of the neural activities in a closed-loop approach.
APPROACH:
The signal analysis is performed online through the implementation of a template matching algorithm. The system performance is demonstrated with the recorded data and in awake rats.
MAIN RESULTS:
Specifically, the neural activities are simultaneously recorded, detected, classified online (through spike sorting) from 32 channels, and used to trigger a light emitting diode light source using generated TTL signals.
SIGNIFICANCE:
A total processing time of 8 ms is achieved, suitable for optogenetic studies of brain mechanisms online

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