04 August 2022 - Research, Media

“There are a million ways this could have failed,” says Vincent Bonin, reflecting on just how remarkably specific the responses of human neurons transplanted in a mouse brain is.

In a recent article zooming in on the ethics of creating hybrid brains, science reporter Kendall Powell interviews both Pierre Vanderhaeghen (VIB-KU Leuven Center for Brain & Disease Research) and Vincent Bonin (NERF) about their collaborative 2019 paper in Neuron, showing how human nerve cells can develop at their own pace, and form highly precise connections with the surrounding mouse brain cells, despite being transplanted into a different species' brain.

Especially because chimeric models may raise new ethical questions, it is important for researchers to discuss new and emerging technologies and model and what they can teach us about the brain, or even brain disorders.

View other articles: