Speaker Thomas McHugh
Affiliation Team Leader, Circuit and Behavioral Physiology, RIKEN Center for Brain Science (CBS)
Time Tuesday, 03 December, 2019, 11:00 am - 12:00 pm
Location imec tower 1.B
Category Seminar

Hosted by Aya Takeoka, Principal Investigator NERF


The hippocampus plays a critical role in memory and its dysfunction can lead to disorders ranging from epilepsy to dementia. Behavioral studies have shown that it is crucial for the formation, recall and consolidation of episodic and contextual memories, but how dynamic changes in its well-characterized neuronal activity map on to these functions, and the theories explaining them, has remained difficult to address.

In rodents, genetic techniques allow specific access to discrete populations of neurons, both within the hippocampus and in areas projecting to it, permitting the manipulation of neuronal transmission and plasticity on a variety of timescales. In this talk I will introduce how we combine these tools with behavior and in vivo recording to gain a greater understanding of how information is processed in the structure.

I will highlight some of the lab’s recent efforts, including experiments designed to understand the links between place cell activity and the encoding of memory, as well as work focused on the identification of a dynamic physiological signature of memory age.